Motif ID: MEF2{A,B,C,D}.p2

Z-value: 4.296


Transcription factors associated with MEF2{A,B,C,D}.p2:

Gene SymbolEntrez IDGene Name
Mef2a 17258 myocyte enhancer factor 2A
Mef2b 17259 myocyte enhancer factor 2B
Mef2c 17260 myocyte enhancer factor 2C
Mef2d 17261 myocyte enhancer factor 2D

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mef2cchr13_+_836430320.417.0e-09Click!
Mef2achr7_-_745176240.281.4e-04Click!
Mef2dchr3_+_879739340.256.9e-04Click!
Mef2bchr8_+_72676676-0.102.0e-01Click!


Activity profile for motif MEF2{A,B,C,D}.p2.

activity profile for motif MEF2{A,B,C,D}.p2


Sorted Z-values histogram for motif MEF2{A,B,C,D}.p2

Sorted Z-values for motif MEF2{A,B,C,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MEF2{A,B,C,D}.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_66981900 148.114 NM_001113387
 Myl1
myosin, light polypeptide 1
chrX_+_154137049 134.514 NM_025357
 Smpx
small muscle protein, X-linked
chrX_+_154137193 133.431 Smpx
small muscle protein, X-linked
chrX_+_154137114 132.268 Smpx
small muscle protein, X-linked
chr11_+_98245124 122.898 NM_011540
 Tcap
titin-cap
chr6_-_14705104 119.130 NM_080464
 Ppp1r3a
protein phosphatase 1, regulatory (inhibitor) subunit 3A
chr1_-_66991625 118.044 NM_021285
 Myl1
myosin, light polypeptide 1
chr1_-_66991580 115.316 Myl1
myosin, light polypeptide 1
chr17_+_71368860 79.481 NM_001083934
NM_010867
 Myom1

myomesin 1

chr6_-_142650737 77.781 NM_001044720
NM_011511
NM_021041
NM_021042
 Abcc9



ATP-binding cassette, sub-family C (CFTR/MRP), member 9



chr2_+_32483909 76.343 NM_001198792
 Ak1
adenylate kinase 1
chr11_+_67013553 72.465 NM_030679
 Myh1
myosin, heavy polypeptide 1, skeletal muscle, adult
chr14_-_21475760 72.068 NM_021508
 Myoz1
myozenin 1
chr7_+_149684731 71.377 NM_001163664
NM_001163665
NM_001163666
NM_001163667
NM_001163668
NM_001163669
NM_001163670
NM_011620
 Tnnt3







troponin T3, skeletal, fast







chr16_-_4523061 70.126 Srl
sarcalumenin
chr7_-_135349828 67.768 NM_009943
 Cox6a2
cytochrome c oxidase, subunit VI a, polypeptide 2
chr16_-_4523051 67.659 NM_175347
 Srl
sarcalumenin
chr11_-_5703677 66.286 Pgam2
phosphoglycerate mutase 2
chr11_+_67051530 65.649 NM_010855
 Myh4
myosin, heavy polypeptide 4, skeletal muscle
chr17_+_24869629 65.482 NM_025425
 Rpl3l
ribosomal protein L3-like

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 69 entries
Enrichment   P-value GO Accession GO Term
19.98 7.72e-09 GO:0045214 sarcomere organization
17.71 3.98e-11 GO:0030239 myofibril assembly
14.47 1.69e-10 GO:0031032 actomyosin structure organization
13.83 3.55e-03 GO:0055006 cardiac cell development
13.83 3.55e-03 GO:0055013 cardiac muscle cell development
9.99 1.98e-13 GO:0055002 striated muscle cell development
9.59 2.34e-14 GO:0055001 muscle cell development
9.59 1.80e-03 GO:0055010 ventricular cardiac muscle tissue morphogenesis
9.22 5.51e-06 GO:0060415 muscle tissue morphogenesis
9.22 2.53e-03 GO:0003229 ventricular cardiac muscle tissue development
8.81 1.90e-04 GO:0055008 cardiac muscle tissue morphogenesis
8.45 7.02e-05 GO:0006941 striated muscle contraction
8.27 6.35e-03 GO:0055007 cardiac muscle cell differentiation
8.17 1.71e-03 GO:0003208 cardiac ventricle morphogenesis
7.82 4.43e-05 GO:0048644 muscle organ morphogenesis
7.80 3.74e-09 GO:0048738 cardiac muscle tissue development
7.56 5.18e-14 GO:0051146 striated muscle cell differentiation
7.49 7.46e-05 GO:0048747 muscle fiber development
7.31 1.31e-03 GO:0035051 cardiac cell differentiation
6.75 9.47e-16 GO:0014706 striated muscle tissue development

Gene overrepresentation in compartment category:

Showing 1 to 20 of 44 entries
Enrichment   P-value GO Accession GO Term
22.47 1.06e-05 GO:0005861 troponin complex
19.98 5.17e-03 GO:0031430 M band
15.98 2.28e-06 GO:0005865 striated muscle thin filament
13.62 4.71e-03 GO:0016460 myosin II complex
13.32 4.01e-02 GO:0005859 muscle myosin complex
11.99 1.54e-03 GO:0031672 A band
11.52 1.24e-02 GO:0005583 fibrillar collagen
10.42 6.81e-22 GO:0030017 sarcomere
9.99 2.46e-23 GO:0044449 contractile fiber part
9.99 1.94e-11 GO:0030018 Z disc
9.99 2.74e-02 GO:0043230 extracellular organelle
9.99 2.74e-02 GO:0065010 extracellular membrane-bounded organelle
9.91 2.14e-27 GO:0043292 contractile fiber
9.73 2.90e-24 GO:0030016 myofibril
8.76 5.86e-11 GO:0031674 I band
8.17 1.88e-02 GO:0014704 intercalated disc
8.17 1.88e-02 GO:0044291 cell-cell contact zone
8.07 4.98e-03 GO:0005581 collagen
7.85 2.58e-05 GO:0016529 sarcoplasmic reticulum
7.82 6.99e-06 GO:0016528 sarcoplasm

Gene overrepresentation in function category:

Showing 1 to 9 of 9 entries
Enrichment   P-value GO Accession GO Term
29.96 1.46e-02 GO:0030172 troponin C binding
13.62 6.27e-03 GO:0042805 actinin binding
11.37 4.13e-07 GO:0005200 structural constituent of cytoskeleton
3.71 1.85e-02 GO:0019838 growth factor binding
3.50 5.07e-08 GO:0003779 actin binding
3.31 1.31e-12 GO:0008092 cytoskeletal protein binding
2.41 2.55e-03 GO:0005198 structural molecule activity
1.40 3.00e-07 GO:0005515 protein binding
1.15 1.88e-02 GO:0005488 binding