Motif ID: MEF2{A,B,C,D}.p2

Z-value: 4.296


Transcription factors associated with MEF2{A,B,C,D}.p2:

Gene SymbolEntrez IDGene Name
Mef2a 17258 myocyte enhancer factor 2A
Mef2b 17259 myocyte enhancer factor 2B
Mef2c 17260 myocyte enhancer factor 2C
Mef2d 17261 myocyte enhancer factor 2D

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mef2cchr13_+_836430320.417.0e-09Click!
Mef2achr7_-_745176240.281.4e-04Click!
Mef2dchr3_+_879739340.256.9e-04Click!
Mef2bchr8_+_72676676-0.102.0e-01Click!


Activity profile for motif MEF2{A,B,C,D}.p2.

activity profile for motif MEF2{A,B,C,D}.p2


Sorted Z-values histogram for motif MEF2{A,B,C,D}.p2

Sorted Z-values for motif MEF2{A,B,C,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MEF2{A,B,C,D}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_66981900 148.114 NM_001113387
Myl1
myosin, light polypeptide 1
chrX_+_154137049 134.514 NM_025357
Smpx
small muscle protein, X-linked
chrX_+_154137193 133.431 Smpx
small muscle protein, X-linked
chrX_+_154137114 132.268 Smpx
small muscle protein, X-linked
chr11_+_98245124 122.898 NM_011540
Tcap
titin-cap
chr6_-_14705104 119.130 NM_080464
Ppp1r3a
protein phosphatase 1, regulatory (inhibitor) subunit 3A
chr1_-_66991625 118.044 NM_021285
Myl1
myosin, light polypeptide 1
chr1_-_66991580 115.316 Myl1
myosin, light polypeptide 1
chr17_+_71368860 79.481 NM_001083934
NM_010867
Myom1

myomesin 1

chr6_-_142650737 77.781 NM_001044720
NM_011511
NM_021041
NM_021042
Abcc9



ATP-binding cassette, sub-family C (CFTR/MRP), member 9



chr2_+_32483909 76.343 NM_001198792
Ak1
adenylate kinase 1
chr11_+_67013553 72.465 NM_030679
Myh1
myosin, heavy polypeptide 1, skeletal muscle, adult
chr14_-_21475760 72.068 NM_021508
Myoz1
myozenin 1
chr7_+_149684731 71.377 NM_001163664
NM_001163665
NM_001163666
NM_001163667
NM_001163668
NM_001163669
NM_001163670
NM_011620
Tnnt3







troponin T3, skeletal, fast







chr16_-_4523061 70.126 Srl
sarcalumenin
chr7_-_135349828 67.768 NM_009943
Cox6a2
cytochrome c oxidase, subunit VI a, polypeptide 2
chr16_-_4523051 67.659 NM_175347
Srl
sarcalumenin
chr11_-_5703677 66.286 Pgam2
phosphoglycerate mutase 2
chr11_+_67051530 65.649 NM_010855
Myh4
myosin, heavy polypeptide 4, skeletal muscle
chr17_+_24869629 65.482 NM_025425
Rpl3l
ribosomal protein L3-like
chr7_-_148086285 64.725 Cox8b
cytochrome c oxidase, subunit VIIIb
chr14_-_21483775 63.478 Synpo2l
synaptopodin 2-like
chr7_+_149628285 62.029 NM_009405
Tnni2
troponin I, skeletal, fast 2
chr8_+_15057652 60.140 NM_008664
Myom2
myomesin 2
chr11_-_69761489 59.392 NM_009204
Slc2a4
solute carrier family 2 (facilitated glucose transporter), member 4
chr5_+_122550987 59.093 NM_010861
Myl2
myosin, light polypeptide 2, regulatory, cardiac, slow
chr7_+_149627709 59.009 Tnni2
troponin I, skeletal, fast 2
chr11_+_70471297 58.572 NM_007933
Eno3
enolase 3, beta muscle
chr2_+_32480924 58.451 NM_001198791
Ak1
adenylate kinase 1
chr3_+_96329090 57.659 NM_027126
Hfe2
hemochromatosis type 2 (juvenile) (human homolog)
chr1_-_174149963 57.377 Casq1
calsequestrin 1
chr11_+_70471347 56.642 Eno3
enolase 3, beta muscle
chr10_+_32803288 55.300 NM_029726
Trdn
triadin
chr1_-_174149989 55.038 NM_009813
Casq1
calsequestrin 1
chr19_-_56464434 54.796 NM_008733
NM_198059
Nrap

nebulin-related anchoring protein

chr2_+_69508174 54.002 NM_001081087
Kbtbd10
kelch repeat and BTB (POZ) domain containing 10
chr3_-_122737855 52.723 NM_021503
Myoz2
myozenin 2
chr14_-_21475715 52.031 Myoz1
myozenin 1
chr18_+_44493726 51.796 NM_001033621
Myot
myotilin
chr15_+_97962651 50.893


chr3_+_101890431 50.878 NM_009814
Casq2
calsequestrin 2
chr15_-_89256262 50.389 NM_009948
Cpt1b
carnitine palmitoyltransferase 1b, muscle
chr14_-_35401845 49.860 NM_001039071
NM_001039072
NM_001039073
NM_001039075
NM_001039076
NM_011918
Ldb3





LIM domain binding 3





chr11_+_67051128 49.753 Myh4
myosin, heavy polypeptide 4, skeletal muscle
chr7_-_56103405 49.060 NM_001198841
Csrp3
cysteine and glycine-rich protein 3
chr1_-_174228105 48.614 NM_178405
Atp1a2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr15_-_89256252 48.225 Cpt1b
carnitine palmitoyltransferase 1b, muscle
chrX_+_160876032 48.002 NM_026853
Asb11
ankyrin repeat and SOCS box-containing 11
chr7_-_56103389 47.769 Csrp3
cysteine and glycine-rich protein 3
chr4_+_155590035 47.694 NM_172417
2310042D19Rik
RIKEN cDNA 2310042D19 gene
chrX_+_98644459 46.829 Itgb1bp2
integrin beta 1 binding protein 2
chr3_+_102877936 46.702 NM_001033303
Ampd1
adenosine monophosphate deaminase 1
chrX_+_98644445 46.696 NM_013712
Itgb1bp2
integrin beta 1 binding protein 2
chr4_+_133871031 46.420 NM_001039048
Trim63
tripartite motif-containing 63
chr14_-_35401654 45.908 NM_001039074
Ldb3
LIM domain binding 3
chr10_-_106931783 45.180 NM_008657
Myf6
myogenic factor 6
chr10_-_88067758 40.373 NM_175418
Mybpc1
myosin binding protein C, slow-type
chr4_+_140977613 40.282 Hspb7
heat shock protein family, member 7 (cardiovascular)
chr11_+_67611772 40.062 NM_001013013
Dhrs7c
dehydrogenase/reductase (SDR family) member 7C
chr5_-_116872852 39.804 NM_030704
Hspb8
heat shock protein 8
chr9_-_119932620 39.723 NM_011724
Xirp1
xin actin-binding repeat containing 1
chr15_+_101097276 39.059 NM_010444
Nr4a1
nuclear receptor subfamily 4, group A, member 1
chr5_+_136363914 38.971 Hspb1
heat shock protein 1
chr13_-_93914519 38.196 NM_023821
Cmya5
cardiomyopathy associated 5
chr5_+_136363810 37.974 Hspb1
heat shock protein 1
chr7_-_148086341 37.562 NM_007751
Cox8b
cytochrome c oxidase, subunit VIIIb
chr5_-_51945054 37.551 NM_008904
Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
chr11_-_5703752 37.472 NM_018870
Pgam2
phosphoglycerate mutase 2
chr1_+_93247592 37.355 NM_027551
Klhl30
kelch-like 30 (Drosophila)
chr5_+_136363769 37.323 NM_013560
Hspb1
heat shock protein 1
chr4_+_129985957 37.227 NM_010174
Fabp3
fatty acid binding protein 3, muscle and heart
chr6_+_55286292 37.089 NM_007472
Aqp1
aquaporin 1
chrX_+_10173557 36.922


chr4_-_73596693 36.867 NM_027104
NM_027981
2310002L09Rik

RIKEN cDNA 2310002L09 gene

chr10_+_97028134 36.853 NM_008524
Lum
lumican
chr14_+_56194658 36.578 Fitm1
fat storage-inducing transmembrane protein 1
chr14_+_56194510 36.407 NM_026808
Fitm1
fat storage-inducing transmembrane protein 1
chr14_+_56194622 36.317 Fitm1
fat storage-inducing transmembrane protein 1
chr14_-_21487489 36.105 NM_175132
Synpo2l
synaptopodin 2-like
chr7_+_88202481 36.029 NM_054085
Alpk3
alpha-kinase 3
chr4_-_9570742 35.843 Asph
aspartate-beta-hydroxylase
chr11_-_94837640 35.790 NM_009161
Sgca
sarcoglycan, alpha (dystrophin-associated glycoprotein)
chr4_+_46052090 34.703 NM_021883
Tmod1
tropomodulin 1
chr14_+_27707789 34.382 NM_001170748
NM_080856
Asb14

ankyrin repeat and SOCS box-containing 14

chr5_-_122906470 34.307 Atp2a2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
chr1_-_45559866 33.380 Col5a2
collagen, type V, alpha 2
chr14_-_21475679 33.307 Myoz1
myozenin 1
chr12_+_113858217 33.096 NM_007421
Adssl1
adenylosuccinate synthetase like 1
chr5_+_67137054 32.799 NM_001001980
Limch1
LIM and calponin homology domains 1
chr16_+_5885447 32.356 Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr9_-_101101334 31.755 NM_172144
Ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chr11_-_20729367 31.199 1110067D22Rik
RIKEN cDNA 1110067D22 gene
chr1_-_45559904 31.141 Col5a2
collagen, type V, alpha 2
chr13_-_114453813 30.995 NM_019960
Hspb3
heat shock protein 3
chr5_-_17394776 30.570 NM_001159558
Cd36
CD36 antigen
chr6_+_4455686 30.035 NM_007743
Col1a2
collagen, type I, alpha 2
chr14_+_102239673 29.949 Lmo7
LIM domain only 7
chr12_+_53800369 29.808 NM_198111
Akap6
A kinase (PRKA) anchor protein 6
chr2_-_64860728 29.690 NM_016719
Grb14
growth factor receptor bound protein 14
chr4_+_140977621 29.651 Hspb7
heat shock protein family, member 7 (cardiovascular)
chrX_-_92673432 29.173 NM_080858
Asb12
ankyrin repeat and SOCS box-containing 12
chr3_+_116265890 29.105 NM_027321
NM_175413
Lrrc39

leucine rich repeat containing 39

chr4_-_9570815 28.657 NM_001177852
NM_001177853
NM_001177854
NM_133723
Asph



aspartate-beta-hydroxylase



chr1_+_137695997 28.564 NM_021467
NM_001112702
Tnni1

troponin I, skeletal, slow 1

chr3_+_137004089 28.150 Emcn
endomucin
chr16_-_85455370 28.145


chr2_+_120289460 27.913 Capn3
calpain 3
chr19_-_40476799 27.611 NM_001034964
Sorbs1
sorbin and SH3 domain containing 1
chr3_-_142058569 27.526 Pdlim5
PDZ and LIM domain 5
chr5_-_130354822 27.183 NM_011079
Phkg1
phosphorylase kinase gamma 1
chr16_+_45093784 27.082 Ccdc80
coiled-coil domain containing 80
chr2_+_120289326 27.049 NM_001177799
NM_007601
Capn3

calpain 3

chr8_-_25549415 26.752 NM_026931
1810011O10Rik
RIKEN cDNA 1810011O10 gene
chr3_+_32716447 26.686 NM_001013024
Usp13
ubiquitin specific peptidase 13 (isopeptidase T-3)
chr8_-_25549374 26.563 1810011O10Rik
RIKEN cDNA 1810011O10 gene
chr4_+_135803834 26.352 NM_011542
Tcea3
transcription elongation factor A (SII), 3
chr3_+_137004041 26.172 NM_001163522
NM_016885
Emcn

endomucin

chr1_-_45559700 25.291 Col5a2
collagen, type V, alpha 2
chr6_+_112223751 25.257 NM_144799
Lmcd1
LIM and cysteine-rich domains 1
chr7_-_123174560 25.079 NM_001025560
Sox6
SRY-box containing gene 6
chr2_-_76820599 24.860 NM_011652
NM_028004
Ttn

titin

chr9_+_121686724 24.814 NM_028202
Kbtbd5
kelch repeat and BTB (POZ) domain containing 5
chr7_+_52661329 24.120 NM_010596
Kcna7
potassium voltage-gated channel, shaker-related subfamily, member 7
chr5_-_17394564 23.664 Cd36
CD36 antigen
chr3_-_10208575 23.631 NM_024406
Fabp4
fatty acid binding protein 4, adipocyte
chr6_-_97202685 23.565 NM_001081157
Lmod3
leiomodin 3 (fetal)
chr8_-_47296201 23.403 NM_007450
Slc25a4
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4
chr11_-_120509650 23.184 NM_026751
Myadml2
myeloid-associated differentiation marker-like 2
chr15_+_31498611 23.180 NM_181588
Cmbl
carboxymethylenebutenolidase-like (Pseudomonas)
chr1_-_45560001 22.906 NM_007737
Col5a2
collagen, type V, alpha 2
chr7_-_31839825 22.172 NM_052991
NM_194321
Fxyd1

FXYD domain-containing ion transport regulator 1

chr8_+_24168730 22.061 NM_031158
Ank1
ankyrin 1, erythroid
chr10_+_126938744 22.046 NM_177707
Stac3
SH3 and cysteine rich domain 3
chr8_+_122190264 21.762 NM_023395
Wfdc1
WAP four-disulfide core domain 1
chr1_+_137732910 21.534 Tnnt2
troponin T2, cardiac
chr1_-_72920776 21.368 Igfbp5
insulin-like growth factor binding protein 5
chr8_+_55635768 21.176 Asb5
ankyrin repeat and SOCs box-containing 5
chr13_-_115078961 21.092 Ndufs4
NADH dehydrogenase (ubiquinone) Fe-S protein 4
chr2_+_31951149 20.438 NM_145521
Ppapdc3
phosphatidic acid phosphatase type 2 domain containing 3
chr5_-_69933835 20.358 NM_023784
Yipf7
Yip1 domain family, member 7
chr1_+_75356906 20.351 Des
desmin
chr10_-_62666659 19.901 NM_182992
Mypn
myopalladin
chr16_+_43640198 19.851 Zbtb20
zinc finger and BTB domain containing 20
chr11_+_72974053 19.423 P2rx5
purinergic receptor P2X, ligand-gated ion channel, 5
chr10_+_80657435 19.318 2310050B05Rik
RIKEN cDNA 2310050B05 gene
chr14_-_104213981 19.276


chr6_-_71212223 19.098 NM_001160127
NM_009762
Smyd1

SET and MYND domain containing 1

chr8_+_46744023 19.079 Sorbs2
sorbin and SH3 domain containing 2
chr15_-_41700964 19.038 NM_175456
Abra
actin-binding Rho activating protein
chr2_+_120302644 18.866 NM_001109761
Capn3
calpain 3
chr12_+_37835132 18.854 NM_008584
Meox2
mesenchyme homeobox 2
chr12_+_70342818 18.770 NM_178253
Klhdc1
kelch domain containing 1
chr10_-_80664743 18.753 NM_027120
Itgb1bp3
integrin beta 1 binding protein 3
chr7_-_104566013 18.704 NM_009381
Thrsp
thyroid hormone responsive SPOT14 homolog (Rattus)
chr1_-_137268058 18.680 Shisa4
shisa homolog 4 (Xenopus laevis)
chr14_+_66587319 18.318 NM_013492
Clu
clusterin
chr1_+_75371871 18.201 NM_007463
Speg
SPEG complex locus
chr1_+_166726827 17.846 NM_019759
Dpt
dermatopontin
chr18_-_12914177 17.351 Osbpl1a
oxysterol binding protein-like 1A
chr13_-_62959656 17.341 NM_007994
Fbp2
fructose bisphosphatase 2
chr6_+_112409684 17.332 Cav3
caveolin 3
chr9_-_77195596 17.207 NM_027150
2310046A06Rik
2810047F03Rik
RIKEN cDNA 2310046A06 gene
RIKEN cDNA 2810047F03 gene
chr17_-_14831058 17.113 Thbs2
thrombospondin 2
chr3_+_137949734 16.746 Adh1
alcohol dehydrogenase 1 (class I)
chr3_-_10208480 16.708 Fabp4
Fabp9
fatty acid binding protein 4, adipocyte
fatty acid binding protein 9, testis
chr3_-_129458190 16.655 NM_010113
Egf
epidermal growth factor
chr14_+_48268985 16.446 Ktn1
kinectin 1
chr17_-_14831095 16.414 Thbs2
thrombospondin 2
chr13_-_62959751 16.055 Fbp2
fructose bisphosphatase 2
chr7_-_106494110 16.026


chr9_-_79825502 15.979 NM_001081243
Filip1
filamin A interacting protein 1
chr9_+_54442900 15.961 Idh3a
isocitrate dehydrogenase 3 (NAD+) alpha
chr4_+_48676385 15.952 NM_026509
Murc
muscle-related coiled-coil protein
chr11_-_101285982 15.948 1700113I22Rik
RIKEN cDNA 1700113I22 gene
chr11_-_69211724 15.688 NM_025915
Tmem88
transmembrane protein 88
chr5_-_17341512 15.234 Cd36
CD36 antigen
chr4_-_108311676 15.164


chr11_+_67090625 15.082 NM_177369
Myh8
myosin, heavy polypeptide 8, skeletal muscle, perinatal
chr5_+_25265761 15.060 NM_001004365
Actr3b
ARP3 actin-related protein 3 homolog B (yeast)
chr15_+_73578771 14.829 Ptp4a3
protein tyrosine phosphatase 4a3
chr1_-_72921438 14.816 NM_010518
Igfbp5
insulin-like growth factor binding protein 5
chr17_+_75835208 14.809 NM_001166493
Rasgrp3
RAS, guanyl releasing protein 3
chr6_+_116600624 14.618 NM_001166580
NM_145980
8430408G22Rik

RIKEN cDNA 8430408G22 gene

chr9_-_66880619 14.284 Tpm1
tropomyosin 1, alpha
chr16_+_56477956 14.134 NM_001014399
NM_001014422
NM_001014423
NM_001014424
NM_178790
Abi3bp




ABI gene family, member 3 (NESH) binding protein




chr4_+_104829951 13.914 NM_080555
Ppap2b
phosphatidic acid phosphatase type 2B
chr2_-_62411970 13.912 NM_007986
Fap
fibroblast activation protein
chr10_-_24919916 13.757 Akap7
A kinase (PRKA) anchor protein 7
chr5_-_124053691 13.678 Clip1
CAP-GLY domain containing linker protein 1
chr1_+_137732961 13.662 NM_001130174
NM_001130175
NM_001130177
NM_001130178
NM_001130179
NM_001130180
NM_001130181
NM_011619
NM_001136083
Tnnt2








troponin T2, cardiac








chr7_+_120909625 13.572 Spon1
spondin 1, (f-spondin) extracellular matrix protein
chr2_-_125142715 13.541 Fbn1
fibrillin 1
chr16_+_45093816 13.464 Ccdc80
coiled-coil domain containing 80
chr6_+_4471231 13.431 Col1a2
collagen, type I, alpha 2
chr4_+_57907032 13.431 Akap2
A kinase (PRKA) anchor protein 2
chr11_+_70470701 13.426 NM_001136062
Eno3
enolase 3, beta muscle
chr19_-_37250472 13.408 Cpeb3
cytoplasmic polyadenylation element binding protein 3
chr3_-_122939013 13.375 NM_080451
Synpo2
synaptopodin 2
chr11_+_94189524 13.341 Ankrd40
ankyrin repeat domain 40
chr2_+_31951030 13.329 Ppapdc3
phosphatidic acid phosphatase type 2 domain containing 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
5.47 5.22e-18 GO:0061061 muscle structure development
6.62 1.70e-16 GO:0060537 muscle tissue development
6.75 9.47e-16 GO:0014706 striated muscle tissue development
9.59 2.34e-14 GO:0055001 muscle cell development
7.56 5.18e-14 GO:0051146 striated muscle cell differentiation
6.35 7.01e-14 GO:0042692 muscle cell differentiation
9.99 1.98e-13 GO:0055002 striated muscle cell development
5.88 7.35e-13 GO:0007517 muscle organ development
6.58 8.24e-12 GO:0003012 muscle system process
17.71 3.98e-11 GO:0030239 myofibril assembly
6.72 1.66e-10 GO:0006936 muscle contraction
14.47 1.69e-10 GO:0031032 actomyosin structure organization
2.51 2.20e-09 GO:0009888 tissue development
7.80 3.74e-09 GO:0048738 cardiac muscle tissue development
19.98 7.72e-09 GO:0045214 sarcomere organization
3.64 2.92e-07 GO:0007507 heart development
1.67 6.06e-07 GO:0048856 anatomical structure development
2.79 6.93e-07 GO:0072358 cardiovascular system development
2.79 6.93e-07 GO:0072359 circulatory system development
1.57 3.31e-06 GO:0032502 developmental process
1.68 4.26e-06 GO:0048731 system development
9.22 5.51e-06 GO:0060415 muscle tissue morphogenesis
1.59 6.10e-06 GO:0007275 multicellular organismal development
1.89 8.57e-06 GO:0051239 regulation of multicellular organismal process
1.79 1.79e-05 GO:0048513 organ development
5.85 1.98e-05 GO:0007519 skeletal muscle tissue development
5.64 3.40e-05 GO:0060538 skeletal muscle organ development
5.64 3.40e-05 GO:0090257 regulation of muscle system process
7.82 4.43e-05 GO:0048644 muscle organ morphogenesis
8.45 7.02e-05 GO:0006941 striated muscle contraction
7.49 7.46e-05 GO:0048747 muscle fiber development
2.76 7.85e-05 GO:0044057 regulation of system process
2.13 1.18e-04 GO:0048468 cell development
1.85 1.65e-04 GO:0009653 anatomical structure morphogenesis
8.81 1.90e-04 GO:0055008 cardiac muscle tissue morphogenesis
4.35 2.95e-04 GO:0003007 heart morphogenesis
1.69 4.45e-04 GO:0065008 regulation of biological quality
1.94 7.19e-04 GO:0050793 regulation of developmental process
7.31 1.31e-03 GO:0035051 cardiac cell differentiation
5.34 1.44e-03 GO:0006937 regulation of muscle contraction
8.17 1.71e-03 GO:0003208 cardiac ventricle morphogenesis
9.59 1.80e-03 GO:0055010 ventricular cardiac muscle tissue morphogenesis
3.37 2.31e-03 GO:0008015 blood circulation
1.61 2.52e-03 GO:0030154 cell differentiation
3.35 2.52e-03 GO:0003013 circulatory system process
9.22 2.53e-03 GO:0003229 ventricular cardiac muscle tissue development
3.45 2.87e-03 GO:0043062 extracellular structure organization
4.99 3.16e-03 GO:0010927 cellular component assembly involved in morphogenesis
13.83 3.55e-03 GO:0055006 cardiac cell development
13.83 3.55e-03 GO:0055013 cardiac muscle cell development
1.96 3.97e-03 GO:2000026 regulation of multicellular organismal development
4.00 4.55e-03 GO:0010038 response to metal ion
2.25 5.91e-03 GO:0051094 positive regulation of developmental process
6.24 6.21e-03 GO:0003231 cardiac ventricle development
8.27 6.35e-03 GO:0055007 cardiac muscle cell differentiation
3.22 8.08e-03 GO:0010035 response to inorganic substance
2.30 8.59e-03 GO:0032989 cellular component morphogenesis
1.56 9.25e-03 GO:0048869 cellular developmental process
4.73 1.42e-02 GO:0008016 regulation of heart contraction
1.95 1.59e-02 GO:0045595 regulation of cell differentiation
3.75 2.08e-02 GO:0008217 regulation of blood pressure
2.84 2.11e-02 GO:0030029 actin filament-based process
2.89 2.62e-02 GO:0030036 actin cytoskeleton organization
2.39 2.65e-02 GO:0048729 tissue morphogenesis
5.35 2.66e-02 GO:0003206 cardiac chamber morphogenesis
2.58 3.05e-02 GO:0001568 blood vessel development
2.02 4.14e-02 GO:0009887 organ morphogenesis
2.46 4.66e-02 GO:0001944 vasculature development
4.99 4.99e-02 GO:0003205 cardiac chamber development

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
9.91 2.14e-27 GO:0043292 contractile fiber
9.73 2.90e-24 GO:0030016 myofibril
9.99 2.46e-23 GO:0044449 contractile fiber part
10.42 6.81e-22 GO:0030017 sarcomere
9.99 1.94e-11 GO:0030018 Z disc
8.76 5.86e-11 GO:0031674 I band
3.63 2.62e-08 GO:0015629 actin cytoskeleton
1.40 4.51e-07 GO:0044444 cytoplasmic part
15.98 2.28e-06 GO:0005865 striated muscle thin filament
5.78 3.76e-06 GO:0042383 sarcolemma
1.27 6.36e-06 GO:0005737 cytoplasm
7.82 6.99e-06 GO:0016528 sarcoplasm
22.47 1.06e-05 GO:0005861 troponin complex
7.85 2.58e-05 GO:0016529 sarcoplasmic reticulum
2.05 2.59e-05 GO:0005626 insoluble fraction
6.54 5.99e-05 GO:0016459 myosin complex
1.98 9.14e-05 GO:0044421 extracellular region part
1.77 9.93e-05 GO:0005856 cytoskeleton
1.84 1.67e-04 GO:0000267 cell fraction
4.10 5.11e-04 GO:0044420 extracellular matrix part
2.74 1.04e-03 GO:0005578 proteinaceous extracellular matrix
11.99 1.54e-03 GO:0031672 A band
1.16 2.10e-03 GO:0044424 intracellular part
1.19 2.47e-03 GO:0043229 intracellular organelle
1.49 2.54e-03 GO:0043228 non-membrane-bounded organelle
1.49 2.54e-03 GO:0043232 intracellular non-membrane-bounded organelle
1.16 3.02e-03 GO:0005622 intracellular
1.19 3.33e-03 GO:0043226 organelle
13.62 4.71e-03 GO:0016460 myosin II complex
8.07 4.98e-03 GO:0005581 collagen
19.98 5.17e-03 GO:0031430 M band
1.83 6.14e-03 GO:0005624 membrane fraction
7.49 8.47e-03 GO:0009925 basal plasma membrane
2.41 1.01e-02 GO:0031012 extracellular matrix
11.52 1.24e-02 GO:0005583 fibrillar collagen
8.17 1.88e-02 GO:0014704 intercalated disc
8.17 1.88e-02 GO:0044291 cell-cell contact zone
2.07 2.02e-02 GO:0045202 synapse
1.85 2.59e-02 GO:0005615 extracellular space
9.99 2.74e-02 GO:0043230 extracellular organelle
9.99 2.74e-02 GO:0065010 extracellular membrane-bounded organelle
6.17 3.23e-02 GO:0045178 basal part of cell
13.32 4.01e-02 GO:0005859 muscle myosin complex
2.58 4.82e-02 GO:0016323 basolateral plasma membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
3.31 1.31e-12 GO:0008092 cytoskeletal protein binding
3.50 5.07e-08 GO:0003779 actin binding
1.40 3.00e-07 GO:0005515 protein binding
11.37 4.13e-07 GO:0005200 structural constituent of cytoskeleton
2.41 2.55e-03 GO:0005198 structural molecule activity
13.62 6.27e-03 GO:0042805 actinin binding
29.96 1.46e-02 GO:0030172 troponin C binding
3.71 1.85e-02 GO:0019838 growth factor binding
1.15 1.88e-02 GO:0005488 binding